Fluid therapy is an important means of modern clinical treatment, as an important means of complement humoral and provide a variety of nutrients in the body of preferential measures, infusion of insoluble particles can cause disease of heart head blood-vessel, pulmonary embolism risk factors, the generation of insoluble particles and production enterprise level of processing technology, production control, clinical infusion operation, drug combination, cork, Filter material aspects may be relevant.
Study on filter of liquid medicine
The provisions of the state apparatus infusionis must install filters can be used for clinical purposes of liquids, liquid medicine filter use is one of the effective methods to prevent particles from entering the human body, the national standard of GH8368 particle antibacterial rate of liquid filter requirements, and industry standard YY086.1, the design of liquid filter, particle pollution, filtration efficiency, infusion velocity are required.
Study on filter membrane
When designing filter, we should pay enough attention to the selection of membrane material, quality, the dynamic indicators of infusion process. The study of liquid filter combined with clinical practical application, simulation of infusion method, from different levels and side tube wipe to understand various filter membrane.
The effect of filter membrane aperture
Filter membrane aperture is an important prerequisite to ensure particle removal rate, the selection of pharmaceutical filter membrane should be dominated by 0.8um-1.2um aperture filter material, after several tests, can ensure a higher filtration efficiency, but also can reach the filter speed requirements of the filter membrane include: Fiber composite membrane, polyester heavy ion film, nylon film, flow attenuation test research shows that the membrane pore size, the greater the material is loose, the smaller the filtration velocity attenuation, and vice versa, it shows that various membrane on particulate matter – tiny particles in the liquid has a different degree of entrapment and adsorption, the deceleration slowed, caused by blocked part of the membrane pore size polyester after infusion in weight increase, the heavy ion membrane filtration speed gradually slow down, The polypropylene non-woven film is a deep filter film, large pore size, disorganized, particles interception mainly depends on the thickness of the film.
Membrane filter material into infusion rate of particle filter test shows that the influence of different material of membrane aperture is the same, although said all have differences, but give the effect of particle rate in the process of transfusion, membrane contact with solution for a long time, the material of the fiber, impurities may be due to the membrane solution, the surface density of membrane layer of loose and fall off into the liquid, through intravenous input and produce potential hazards, Fiber shedding number can be due to different filter material and there are obvious differences, although the number of filtration is the same, but the heavy ion film is obviously superior to polypropylene non-woven film, goods and fiber film, nylon film because the surface has a dense layer is not easy to shed fiber, filter material for infusion filter is ideal.
The influence of adsorption effect: all filter membranes have different degrees of adsorption effect on intravenous drugs, especially on low-dose drugs, and some filter membranes have special heterotropic adsorption on drugs. From the point of the average adsorption rate, low heavy ion membrane, polyether sulfone membrane on drug adsorption, the adsorption effect of infusion of drugs and drug related species, and the line length is related to drug adsorption is determined by the membrane material, the surface of the membrane structure and the structure of the filter, adsorption of drugs also have bigger difference, membrane materials with static in order to improve the particle entrapment more, And easy to overlook the electrostatic adsorption of drugs, so should choose as far as possible thin, small adsorption of inert materials for membrane, or the use of special processing method to eliminate electrostatic effect, infusion tube has a larger surface area, adsorption of drugs have some improvement production process or increase the pipe inner surface layer, make the drug adsorption quantity to a minimum.
Post time: Aug-09-2022